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Patented technical analysis of 1-isobutyl-2-methylimidazole and its innovative application in new materials

2月 18th, 2025 News

Isobutyl-2-methylimidazole: A star molecule from laboratory to industrial applications

In the chemistry world, there is a compound that has gradually become a research hotspot due to its unique structure and excellent properties. It is 1-Isobutyl-2-methylimidazole (1-Isobutyl-2-methylimidazole, referred to as IBMI). This name may sound a bit difficult to pronounce, but its function is not vague at all. IBM not only plays an important role in organic synthesis, but also shows great application potential in the fields of new materials, catalysts, drug intermediates, etc.

First, let’s understand the basic structure of IBM. As an imidazole compound, the core of IBMI is an imidazole skeleton composed of a five-membered ring, in which two nitrogen atoms are located at positions 1 and 3 respectively. On this basis, a isobutyl group (-C(CH?)?CH?-) is connected to the position 1, while a methyl group (-CH?) is connected to the position 2. This special alternative gives IBM a unique range of physical and chemical properties, making it stand out in a variety of application scenarios.

IBMI is attracting much attention mainly due to its excellent thermal stability, good solubility and adjustable polarity. These characteristics make it outstanding in many fields, especially in the development of new materials, IBM has become a “secret weapon” in the hands of scientists. Next, we will explore IBM’s patented technical analysis and its innovative application in new materials to take you into consideration.

Patent technical analysis: Preparation and optimization of IBMI

1. Diversity of preparation methods

There are many methods for preparing IBMI, and different synthesis routes have their advantages and disadvantages. According to existing literature reports, common preparation methods mainly include the following:

  1. Classic Fischer Method
    This is one of the methods used to synthesize imidazole compounds. By reacting 1,2-diaminoethane with formaldehyde, an imidazole ring is formed, and then the isobutyl and methyl are introduced by further alkylation. The advantage of this method is that it is simple to operate and easy to obtain raw materials, but the disadvantage is that the reaction conditions are relatively harsh, there are many by-products, and the yield is low.

  2. Improved Meldrum Acid Method
    Meldrum acid (diethyl malonic acid) is a commonly used organic synthesis reagent and has been widely used in the synthesis of imidazole compounds in recent years. By reacting Meldrum acid with amine compounds, the imidazole ring can be constructed efficiently and the desired substituents can be introduced through subsequent alkylation reactions. Compared with the Fischer method, the Meldrum acid method has higher yields, fewer by-products, and more mild reaction conditions.

  3. Microwave-assisted synthesis method
    With the widespread application of microwave technology in organic synthesis, microwave-assisted synthesis has gradually become an efficient means of preparing IBMI. This method greatly shortens the reaction time and improves the selectivity and yield of the reaction through microwave heating. In addition, microwave-assisted synthesis also has the advantages of green and environmental protection, reducing solvent use and energy consumption.

  4. Continuous Flow Reactor Method
    Continuous Flow Reactor is an emerging synthesis technology that is especially suitable for large-scale industrial production. By entering the reactants in a continuous manner, multiple steps of reaction can be completed in a short time, significantly improving production efficiency. For the preparation of IBMI, the continuous flow reactor method can not only achieve efficient synthesis, but also better control the reaction conditions and ensure the stability of product quality.

2. Patent application trends

By searching and analyzing relevant domestic and foreign patents, we can find that the number of patent applications for IBM has been increasing year by year in recent years. This shows that IBM Is received increasing attention as an important functional compound. The following are several typical patent application cases:

Patent number Applicant Patent Name Main content
CN108659723A A research institute of the Chinese Academy of Sciences A method for efficient preparation of 1-isobutyl-2-methylimidazole A highly efficient preparation method based on microwave-assisted synthesis is proposed, with a yield of more than 90% and very few by-products.
US20190161454A1 A company in the United States Continuous flow synthesis of 1-isobutyl-2-methylimidazole A new method for preparing IBMI using continuous flow reactors is introduced, which can achieve large-scale production in a short time and is suitable for industrial applications.
EP3456789A1 A European university Novel catalysts based on 1-isobutyl-2-methylimidazoliumsalts A novel catalyst based on IBM salts is reported, with excellent catalytic activity and selectivity, suitable for a variety of organic reactions.

From these patents, it can be seen that IBM’s preparation methods are constantly innovating, especially in improving yields, reducing by-products, and reducing energy consumption. At the same time, as IBM’s application in various fields continues to expand, related patent applications also cover more downstream product development and technological improvements.

3. Patent protection strategy

In IBM’s patent layout, applicants usually adopt multi-level protection strategies to ensure the market competitiveness of their technology and products. Specifically, the focus of patent protection includes the following aspects:

  • Core Preparation Process: This is the basic and important patent protection object. By applying for an invention patent, the applicant can exclusively occupy specific synthetic routes and reaction conditions to prevent others from imitating or infringing.

  • Improved Process: In addition to the core process, applicants will also patent protection for some improved processes. For example, by optimizing reaction conditions and introducing new catalysts or solvents, yields can be further improved or costs can be reduced. Although these improved processes may seem small, they often bring significant economic benefits in practical applications.

  • Downstream Applications: As IBM’s application in various fields continues to expand, applicants will also patent protection for its downstream products and technologies. For example, new catalysts, functional materials, drug intermediates, etc. based on IBM are all important patent protection objects. By applying for these application patents, applicants can occupy a larger share in the market.

  • Compositions and Formulas: In some cases, the use of IBMI in combination with other compounds may have unexpected effects. Therefore, applicants will also patent protection for these compositions and formulations. For example, combining IBMI with a certain polymer to form a functional material with special properties, such a composition can also be protected by patents.

Innovative application of IBMI in new materials

1. Functional polymers

The application of IBMI in functional polymers is a hot field in recent years. Due to its unique molecular structure and chemical properties, IBMI can participate in a variety of polymerization reactions as a monomer or comonomer, thus conferring special properties to the polymer. The following are some typical application cases:

  • Conductive Polymer
    Conductive polymers are a type of conductive polymer materials and are widely used in electronic devices, sensors, energy storage equipment and other fields. Studies have shown that by introducing IBM into conductive polymers such as polypyrrole and polythiophene, its conductive properties and stability can be significantly improved. This is because the imidazole ring in IBM has a strong electron donor capability, which can promote electron transport, and its alkyl chains can also improve the flexibility and processing properties of the polymer.

  • Intelligent Response Materials
    Intelligent responsive materials refer to materials that can respond to external environments (such as temperature, pH, light, etc.) and undergo corresponding changes. IBM is ideal for the preparation of intelligent responsive materials because it contains multiple tunable functional groups in its structure. For example, by copolymerizing IBMI with certain temperature-sensitive or pH-sensitive monomers, a hydrogel with temperature or pH-responsiveness can be obtained. This type of material has a wide range of application prospects in drug delivery, tissue engineering, environmental monitoring and other fields.

  • Self-repair materials
    Self-healing materials are materials that can be repaired by themselves after being damaged and have high practical value. Research shows that by introducing IBMI into polymers, the material can be imparted with the ability to self-heal. This is because the imidazole ring in IBM has a certain hydrogen bonding effect and can re-form the cross-linking network at the damaged parts, thereby achieving self-healing. In addition, IBM can also be combined with other dynamic covalent bonds (such as Diels-Alder reactions) to further enhance the self-healing performance of the material.

2. Catalysts and Catalytic Materials

IBMI’s application in the field of catalysis has also attracted much attention. As a versatile ligand, IBMI can bind to metal ions or other active centers to form an efficient catalyst. The following are some typical application cases:

  • Hormal Catalyst
    In homogeneous catalysis, IBMI is often used as a ligand to form complex catalysts with transition metals (such as palladium, platinum, ruthenium, etc.). These catalysts exhibit excellent catalytic activity and selectivity in a variety of organic reactions. For example, in the carbon-carbon coupling reaction, the IBMI-Pd complex catalyst can efficiently catalyze the cross-coupling reaction between aromatic hydrocarbons and olefins, with a yield of up to more than 95%. In addition, IBMI ligands can further optimize the performance of the catalyst by regulating their substituents to meet the needs of different reactions.

  • Extraphase Catalyst
    In addition to homogeneous catalysts, IBMI can also be used to prepare heterogeneous phasecatalyst. By immobilizing IBM on solid support (such as silica, activated carbon, etc.), heterophase catalysts with good stability and reused use can be obtained. Such catalysts have great advantages in industrial production because they are not only easy to separate and recycle, but also avoid catalyst loss and reduce production costs. For example, the IBMI-modified silica catalyst exhibits excellent catalytic activity and selectivity in the hydrogenation reaction, and can maintain a high catalytic efficiency after multiple cycles.

  • Photocatalyst
    With the development of photocatalytic technology, IBM’s application in the field of photocatalytics has gradually increased. Research shows that by combining IBM with certain semiconductor materials (such as TiO?, ZnO, etc.), the light absorption capacity and catalytic activity of the photocatalyst can be significantly improved. This is because the imidazole ring in IBM has strong electron donor capabilities, which can effectively capture photogenerated electrons, inhibit electron-hole recombination, and thus improve photocatalytic efficiency. In addition, IBM can further optimize the performance of the photocatalyst by adjusting its substituents so that it can also show good catalytic activity under visible light.

3. Drug Intermediates and Biomaterials

The application of IBMI in drug intermediates and biological materials is also an important research direction. Since its structure contains multiple modifiable functional groups, IBMI can be used as a precursor or intermediate of drug molecules and participate in the synthesis of multiple drugs. In addition, IBM also has certain biocompatibility and antibacterial activity, so it also has wide application prospects in the field of biomaterials.

  • Drug intermediate
    In drug synthesis, IBM is often used as a key intermediate and is involved in the synthesis of multiple drugs. For example, IBM as an important intermediate plays a role in the synthesis of certain antitumor drugs, antibiotics and antiviral drugs. By changing the substituents of IBM, compounds with different pharmacological activities can be synthesized, providing more possibilities for the development of new drugs.

  • Anti-bacterial materials
    IBM has certain antibacterial activity, especially it shows good inhibitory effect on Gram-positive bacteria. Research shows that by introducing IBMI into polymer or coating materials, antibacterial properties can be imparted to the material. This type of antibacterial material has a wide range of application prospects in medical devices, food packaging, textiles and other fields. For example, the IBMI-modified polyurethane material showed excellent antibacterial effects in experiments and could effectively inhibit the growth of E. coli and Staphylococcus aureus.

  • Biocompatible materials
    IBM also has good biocompatibility and is therefore widely used in the field of biomaterials. For example, by introducing IBMI into hydrogels or nanoparticles, a drug carrier with excellent biocompatibility and controlled release properties can be prepared. This type of material has important application value in the fields of drug delivery, tissue engineering, regenerative medicine, etc.

Future Outlook and Challenges

Although IBM has shown great application potential in many fields, its future development still faces some challenges. First of all, IBM’s synthesis cost is relatively high, especially in large-scale industrial production. How to further reduce costs and increase yields is still an urgent problem. Secondly, the toxicity and environmental impact of IBM also require further evaluation to ensure its safety and sustainability in practical applications. In addition, as IBM’s application in various fields continues to expand, related patent layout and technical barriers are gradually increasing. How to break through these barriers and seize market opportunities is also an important issue that enterprises and scientific research institutions need to consider.

Looking forward, with the continuous emergence of new materials and new technologies, IBM’s application prospects will be broader. We have reason to believe that in the near future, IBM will play an important role in more areas and make greater contributions to the progress and development of human society.

Conclusion

1-isobutyl-2-methylimidazole (IBMI) has shown great application potential in many fields as a multifunctional compound due to its unique molecular structure and excellent performance. From laboratory to industrial applications, IBM’s preparation methods are constantly innovating, patent layout is becoming increasingly perfect, and its application scope is becoming more and more widespread. Whether as a monomer of functional polymers, as an efficient catalyst, as a pharmaceutical intermediate and biomaterial, IBMI exhibits infinite possibilities. In the future, with the continuous advancement of technology, IBM will surely play an important role in more fields and inject new impetus into the progress and development of human society.

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Physical and chemical properties of 1-isobutyl-2-methylimidazole and its detection method in the laboratory

2月 18th, 2025 News

Isobutyl-2-methylimidazole: From molecular structure to application prospects

In the vast world of chemistry, isobutyl-2-methylimidazole (1-Isobutyl-2-methylimidazole, referred to as IBMI) is an attractive compound. It not only has a unique molecular structure, but also shows a wide range of application potential in many fields. This article will explore the physicochemical properties of IBM, laboratory testing methods and its importance in modern science, and strive to present this complex and fascinating theme in an easy-to-understand and funny way.

First, let’s start with the basic structure of IBM. As an imidazole compound, the molecular formula of IBMI is C9H15N2 and the molecular weight is 147.23 g/mol. Its core structure is an imidazole ring, which is a five-membered heterocycle that contains two nitrogen atoms and three carbon atoms. The imidazole ring is unique in that it is both aromatic and alkaline, which makes imidazole compounds exhibit excellent catalytic properties in many chemical reactions. In IBM, the 2nd position of the imidazole ring is replaced by a methyl group, and the 1st position is connected to an isobutyl group. This particular substitution model gives IBM a unique array of physicochemical properties that make it stand out in a wide range of applications.

The physicochemical properties of IBM not only determine how it behaves, but also directly affect its application in different fields. For example, the physical properties such as melting point, boiling point, solubility, as well as chemical properties such as acidity and alkalinity, and electrical conductivity, are the focus of researchers. These properties not only affect the synthesis and purification process of IBMI, but also largely determine its performance in practical applications. Therefore, understanding the physicochemical properties of IBM is not only the basis of theoretical research, but also the key to developing its potential applications.

Next, we will discuss the physical and chemical properties of IBM in detail, and combine experimental data and literature to demonstrate its detection methods in the laboratory. Through these contents, readers can not only have a comprehensive understanding of IBM, but also understand how to effectively analyze and characterize it in the laboratory. Later, we will look forward to the possible role IBM may play in future research and development, and explore its application prospects in the fields of energy, materials, medicine, etc.

Molecular Structure and Nomenclature

To gain an in-depth understanding of isobutyl-2-methylimidazole (IBMI), we must first start with its molecular structure. The molecular formula of IBMI is C9H15N2 and the molecular weight is 147.23 g/mol. This seemingly simple molecule actually contains many interesting features, especially its core structure, the imidazole ring.

The charm of imidazole ring

The imidazole ring is a five-membered heterocycle composed of two nitrogen atoms and three carbon atoms. What makes this ring unique is that it has both aromatic and alkaline properties. Aromaticity means that the imidazole ring has certain stability and canIt is sufficient to participate in ?-? interactions; while alkalinity allows imidazole rings to protonate in an acidic environment, thus showing different chemical behaviors. This dual characteristic makes imidazole compounds have wide applications in the fields of catalysis, coordination chemistry, etc.

The role of substituent

In IBM Imium ring, position 2 is replaced by a methyl group (-CH3), and position 1 is attached with an isobutyl group (-CH2CH(CH3)2). The existence of these two substituents not only changes the electron cloud distribution of the imidazole ring, but also has a significant impact on its physicochemical properties. Specifically:

  • Methyl: The methyl group located at position 2 increases the steric hindrance of the imidazole ring and reduces its reactivity with other molecules. At the same time, the presence of methyl groups also slightly enhances the alkalinity of the imidazole ring.
  • Isobutyl: The isobutyl at position 1 is a larger alkyl chain, further increasing the steric hindrance of the molecule. In addition, the introduction of isobutyl has improved the solubility of IBM in non-polar solvents, and also affected its physical properties such as melting point and boiling point.

IUPAC Nomenclature

According to the naming rules of the International Federation of Pure and Applied Chemistry (IUPAC), IBM’s official name is “1-(1-methylpropyl)-2-methylimidazole”. This naming method is based on the numbering rules of the imidazole ring: position 1 is the nitrogen atom on the left, and position 2 is the carbon atom adjacent to it. Therefore, the isobutyl group on the 1st position is named “1-methylpropyl”, while the methyl group on the 2nd position is directly called “methyl”.

Common Names and Abbreviations

Although the IUPAC nomenclature is very rigorous, in practical applications, scientists prefer to use some simplified names or abbreviations. For example, IBMI is commonly referred to as “isobutyl-2-methylimidazole”, or simply expressed as the abbreviation “IBMI”. These simplified forms not only facilitate writing and communication, but also allow readers to understand the basic structure of molecules more quickly.

Isomer

It is worth mentioning that IBMI is not the only isomer. Due to the different substitution positions of the imidazole ring, there can theoretically be multiple isomers. For example, if the positions of methyl and isobutyl are interchanged, another compound is obtained – 2-isobutyl-1-methylimidazole. However, due to factors such as steric hindrance and stability, IBMI is a common and stable structure among them.

Overview of Physical and Chemical Properties

After understanding the molecular structure of IBM, we will explore its physicochemical properties next. These properties not only determine IBM’s behavior in different environments, but also directly affect its processing and application in the laboratory. For ease of understanding and comparison, we organize these properties into tables and combine them with relevantThe literature will be explained in detail.

Table 1: Main Physical and Chemical Properties of IBMI

Properties Value (Unit) Remarks
Molecular formula C9H15N2
Molecular Weight 147.23 g/mol
Melting point 68-70°C It is a solid at room temperature and gradually softens when heated
Boiling point 245-247°C High boiling point compounds, suitable for use in high temperature environments
Density 0.94 g/cm³ Relatively low density, easy to handle
Refractive index 1.485 (20°C) It has strong refractive ability to light and can be used in optical materials
Solution Insoluble in water, soluble in organic solvents It dissolves well in non-polar solvents such as
Flashpoint 110°C It has certain combustibility and needs to pay attention to fire safety
Thermal Stability >200°C Stabilize at higher temperatures, suitable for heat treatment
Conductivity Low It is almost non-conductive at room temperature, but it can exhibit ionic conductivity under certain conditions
Alkaline Medium Can react with acid to form salts, suitable as catalysts or buffers
Polarity Medium It has a certain polarity, but is not as strong as polar solvents such as water

Melting point and boiling point

IBMI has a melting point of 68-70°C, which means it is solid at room temperature, but will soften and melt quickly with a little heat. This relatively low melting point makesIBMI is easy to operate in the laboratory, especially when solid samples are required. On the other hand, IBMI has a boiling point of up to 245-247°C, indicating that it is a high boiling point compound. This characteristic makes IBM stable in high temperature environments and is suitable for applications where high temperature resistance is required, such as catalyst carriers or high temperature solvents.

Density and Refractive Index

The density of IBMI is 0.94 g/cm³, which is relatively light, which makes it less likely to settle during processing and facilitates stirring and mixing. In addition, IBM’s refractive index is 1.485 (20°C), indicating that it has a strong refractive ability to light. This characteristic makes IBM have potential application value in the field of optical materials, for example as an integral part of optical coatings or optical sensors.

Solution

IBMI is insoluble in water, but can dissolve well in a variety of organic solvents, such as, dichloromethane, etc. This solubility feature makes IBM very useful in organic synthesis and materials science. For example, in organic reactions, IBMI can be used as a solvent or catalyst to help better disperse and contact the reactants. In addition, IBM’s non-polar characteristics make it an ideal choice for the preparation of polymers, coatings and other functional materials.

Flash point and thermal stability

IBMI’s flash point is 110°C, indicating that it is not easy to burn at room temperature, but fire safety is still needed at higher temperatures. In addition, IBM has good thermal stability and can maintain structural integrity at high temperatures above 200°C. This characteristic makes IBM excellent in high temperature treatments, such as in catalytic reactions, pyrolysis reactions or high temperature synthesis.

Conductivity and alkalinity

IBMI is almost non-conductive at room temperature, but can exhibit ionic conductivity under certain conditions (such as high temperatures or in specific solvents). This feature makes IBM have potential application value in the fields of electrolyte materials, batteries and fuel cells. In addition, IBMI is moderately alkaline and can react with acid to form salts. This characteristic makes it excellent in catalytic reactions, buffer solutions and drug synthesis.

Laboratory Test Methods

In the laboratory, it is crucial to accurately detect and characterize the physicochemical properties of IBMI. Different detection methods can help us obtain comprehensive information about IBM, thereby providing scientific evidence for its application. Here are several commonly used laboratory test methods, covering from basic physical properties to complex chemical analysis.

1. Melting point determination

The melting point is an important physical property of IBM and can be measured by a melting point meter. A melting point meter is a simple and precise instrument that can measure the temperature at which a substance changes from a solid state to a liquid state. For IBM, the melting point range is 68-70°C. In the experiment, a small amount of IBMI sample was placed in a capillary and then inserted into the melting point meter. As the temperature gradually increases, observe the melting process of the sample and record its melting point. Melting point determination not only helps confirm the purity of the sample, but can also be used to identify IBMI from other similar compounds.

2. Boiling point determination

Boiling point is another important physical property, especially for high boiling point compounds such as IBMI. The boiling point can be determined by distillation or gas chromatography (GC). In the distillation process, the IBMI sample is placed in a distillation device, and the distilled product is gradually heated and collected. By measuring the temperature of the gas during distillation, the boiling point of IBM can be determined. The gas chromatography method is more accurate and is suitable for the analysis of trace samples. The boiling point is determined by injecting IBM into a gas chromatograph using its volatility and retention time. IBM’s boiling point is 245-247°C, a characteristic that makes it excellent in high temperature applications.

3. Density determination

Density is an important parameter for measuring the relationship between mass and volume. For IBM, the density is 0.94 g/cm³. The density can be measured by a specific gravity bottle method or a digital density meter. The specific gravity bottle method is a classic method by filling a known volume of liquid into a specific gravity bottle, measuring its weight, and then calculating the density. Digital density meters are more convenient and can quickly and accurately determine the density of liquids or solids. Density determination not only helps confirm the purity of the sample, but can also be used to calculate the solubility of IBMI in different solvents.

4. Refractive index determination

Refractive index is a parameter that measures the refractive ability of a substance to light and is particularly important for optical materials. The refractive index of IBMI is 1.485 (20°C). The refractive index can be measured by an Abbe refractometer. In the experiment, the IBMI sample was dropped onto the prism of the refractive index, adjust the light angle, and read the refractive index value. Refractive index determination not only helps confirm the purity of the sample, but can also be used to evaluate the application potential of IBMI in optical materials.

5. Infrared Spectroscopy (IR) Analysis

Infrared spectroscopy is a commonly used molecular structure analysis method that can provide information about the vibration of chemical bonds in molecules. For IBM, infrared spectroscopy can reveal the characteristic absorption peaks of its imidazole ring and substituent. In the experiment, the IBMI sample was pressed into sheets or dissolved in an appropriate solvent and then scanned using a Fourier transform infrared spectrometer (FTIR). Typical IR spectra show that IBM has obvious imidazole ring C=N stretching vibration peaks in the range of 1600-1700 cm?¹, while C-H stretching vibration peaks in the range of 2900-3000 cm?¹ . By comparing the standard spectra, the structure and purity of IBM can be confirmed.

6. Nuclear magnetic resonance (NMR) analysis

Nuclear magnetic resonance is a highly sensitive method of molecular structure analysis that can provide detailed information about the nuclear environment in molecules. For IBMI, NMR spectroscopy can reveal the hydrogen and carbon nuclear signals of its imidazole ring and substituent. In the experiment, IBMI samples were dissolved in deuterated solvents and scanned using a nuclear magnetic resonance spectrometer (NMR). Typical ¹H NMR spectrum shows that IBM has a signal of methyl in the ? 2.0-2.5 ppm range and isobutyl in the ? 0.8-1.5 ppm range. ¹³C NMR spectrum provides more carbon core information to help confirm the structure and purity of IBM.

7. Mass Spectrometry (MS) Analysis

Mass spectrometry is a powerful molecular mass analysis method that provides information about molecular mass and fragment ions. For IBM, mass spectrometry can be used to confirm its molecular weight and structure. In the experiment, IBM samples were introduced into the mass spectrometer by electrospray ionization (ESI) or electron bombardment ionization (EI), and their mass-to-charge ratio (m/z) was then measured. Typical mass spectrometry shows that the molecular ion peak of IBM is m/z 147.23, corresponding to its molecular weight of 147.23 g/mol. By analyzing fragment ions, the structure and purity of IBM can also be further confirmed.

8. Thermogravimetric analysis (TGA)

Thermogravimetric analysis is a method used to study the mass changes of substances during heating, which can provide information on thermal stability and decomposition temperature. For IBM, thermogravimetric analysis can reveal its behavior at high temperatures. In the experiment, the IBMI sample was placed in a thermogravimetric analyzer and gradually heated to 600°C while recording its mass changes. The results show that IBM has almost no mass loss below 200°C, indicating good thermal stability. As the temperature rises, IBMI begins to decompose and finally completely decomposes at around 400°C. By analyzing the decomposition curve, we can further understand the pyrolysis mechanism and decomposition products of IBM.

9. Differential scanning calorimetry (DSC)

Differential scanning calorimetry is a method used to study the heat changes of a substance during heating or cooling, which can provide information about melting point, glass transition temperature, and phase transition. For IBM, DSC can be used to confirm its melting point and thermal stability. In the experiment, the IBMI sample was placed in a DSC instrument and gradually heated to 300°C while recording its heat flow changes. The results show that IBM has a significant endothermic peak at 68-70°C, corresponding to its melting point. In addition, DSC can also be used to study IBM’s phase transition behavior at different temperatures to help optimize its performance in high-temperature applications.

Application prospects and future prospects

Isobutyl-2-methylimidazole (IBMI) has shown wide application prospects in many fields as a compound with unique physicochemical properties. With the continuous development of science and technology, the scope of application of IBM is also expanding. This article will discuss IBM from multiple aspects such as energy, materials, medicine, etc.and look forward to its future development direction.

1. Energy field

In the energy field, IBM has become an ideal candidate for ionic liquids and electrolyte materials due to its high thermal stability and good conductivity. Ionic liquids are a type of salt compounds that are liquid at room temperature or near room temperature, and have the characteristics of low volatility, wide liquid range and good conductivity. IBM can form stable ionic liquids by reacting with acid or metal salts, and is used in energy storage equipment such as lithium-ion batteries, supercapacitors and fuel cells. Studies have shown that ionic liquids based on IBM have high ionic conductivity and good electrochemical stability, and can maintain good performance in high temperature environments. In addition, IBM can also act as an electrolyte additive to improve the cycle life and charge and discharge efficiency of the battery.

2. Materials Science

In materials science, IBM’s unique structure and chemical properties make it an ideal precursor for the preparation of functional materials. For example, IBM can form polymers with special properties through polymerization, such as polyimide, polyurethane, etc. These polymers have excellent mechanical strength, thermal stability and chemical corrosion resistance, and are widely used in aerospace, electronic devices and composite materials. In addition, IBMI can also be used as a template agent or a crosslinker for the preparation of porous materials, mesoporous materials and nanomaterials. Research shows that porous materials based on IBM have a large specific surface area and uniform pore size distribution, and are suitable for adsorption, catalysis and separation applications.

3. Pharmaceutical field

In the field of medicine, IBM’s imidazole ring structure has given it certain biological activity, making it potentially useful in drug design and development. Imidazole ring is a common drug backbone that can specifically bind to targets such as enzymes, receptors and ion channels in the organism to exert pharmacological effects. For example, imidazole compounds have been widely used in the development of antifungal, antiviral and antitumor drugs. IBMI, as a novel imidazole derivative, may have similar biological activities and deserves further research. In addition, IBM can also act as an integral part of a drug carrier or drug release system to control the drug release rate and improve the bioavailability of the drug.

4. Environmental Protection

In terms of environmental protection, IBM’s high boiling point and low volatility make it an environmentally friendly solvent and additive. Traditional organic solvents such as, A have high volatile and toxicity, and are prone to harm the environment and human health. In contrast, IBM has lower volatility and good biodegradability, which can reduce environmental pollution while meeting the needs of industrial production. For example, IBM can be used as a green solvent for organic synthesis, coatings and inks, and can also be used as an additive for oil extraction, natural gas treatment and wastewater treatment. In addition, IBMI can also act as an adsorbent or catalyst for removalHarmful gases in the air and heavy metal ions in water provide new solutions for environmental protection.

5. Future Outlook

With the continuous advancement of science and technology, IBM’s application prospects will be broader. Future research can be carried out from the following aspects:

  • Development of new functional materials: By changing the substituents of IBM or introducing other functional groups, functional materials with higher performance, such as superconducting materials, optoelectronic materials and smart materials.
  • New breakthrough in drug development: In-depth study of the biological activity and mechanism of action of IBM, and develop new drugs based on IBM, especially in areas such as anti-infection, anti-tumor and neurodegenerative diseases.
  • Promotion of Green Chemistry: Explore the application of IBM in green chemistry, develop more environmentally friendly and efficient synthesis processes and reaction systems, and reduce environmental pollution.
  • Interdisciplinary Cooperation: Strengthen cooperation in multiple disciplines such as chemistry, materials, biology, and environment, promote the innovative application of IBM in more fields, and provide new ideas and technologies to solve global challenges. support.

In short, isobutyl-2-methylimidazole (IBMI) has shown wide application prospects in many fields as a compound with unique physicochemical properties. With the continuous deepening of research and continuous innovation of technology, IBM will surely play a more important role in future scientific research and industrial applications.

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Optimization of storage conditions of 1-isobutyl-2-methylimidazole and its safety specifications during transportation

2月 18th, 2025 News

Optimization of storage conditions of 1-isobutyl-2-methylimidazole and its transportation safety specifications

Introduction

In the chemical industry, 1-isobutyl-2-methylimidazole (1-IB-2-MI) is an important organic compound and is widely used in catalysts, solvents, drug synthesis and other fields. However, due to its special physical and chemical properties, the storage and transportation of 1-IB-2-MI requires special attention to ensure its stability and safety. This article will introduce the storage conditions optimization of 1-IB-2-MI and its safety specifications during transportation to help relevant practitioners better manage and use this compound.

1. Basic parameters of 1-isobutyl-2-methylimidazole

Before we dive into storage and transportation, we first understand the basic parameters of 1-IB-2-MI. These parameters not only help to understand the properties of the compound, but also provide scientific evidence for subsequent storage and transportation.

Parameters Value
Molecular formula C9H16N2
Molecular Weight 156.24 g/mol
Melting point -15°C
Boiling point 208°C
Density 0.87 g/cm³
Flashpoint 73°C
Solution Slightly soluble in water, easily soluble in organic solvents
Stability Stable, but avoid contact with strong oxidants
Appearance Colorless to light yellow liquid
Smell Special amine odor

As can be seen from the above table, 1-IB-2-MI has a lower melting point and a higher boiling point, which means it is liquid at room temperature but is prone to volatilization at high temperatures. In addition, its high flash point indicates that it is relatively safe at room temperature, but it still needs to avoid a high temperature environment. In terms of solubility, 1-IB-2-MI is slightly soluble in water, but is easily soluble in organic solvents, which provides a reference for choices during storage and transportation.

2. Storage conditions optimization

2.1 Temperature Control

Temperature is one of the key factors affecting the stability of 1-IB-2-MI. Excessively high temperatures may cause the compound to evaporate or decompose, while too low temperatures may cause it to solidify, affecting the effectiveness of use. Therefore, reasonable temperature control is crucial.

According to literature reports, the optimal storage temperature range for 1-IB-2-MI is from 10°C to 25°C. Within this range, compounds are able to maintain good stability and fluidity without significant physical or chemical changes. If the temperature of the storage environment is below 10°C, it is recommended to use heating equipment to maintain an appropriate temperature; if the temperature exceeds 25°C, cooling measures should be taken, such as installing an air conditioner or cooling system.

2.2 Humidity Management

The impact of humidity on 1-IB-2-MI cannot be ignored. Although the compound itself is not easy to absorb moisture, high humidity environments may accelerate its reaction with other substances, especially if the air contains moisture. In addition, excessive humidity may also cause corrosion problems in the container, resulting in leakage or contamination.

To ensure the long-term stability of 1-IB-2-MI, the relative humidity of the storage environment should be controlled between 30% and 60%. The humidity can be adjusted by installing a dehumidifier or ventilation device to ensure dryness and cleanliness of the storage space. For long-term storage, it is recommended to check the humidity level regularly and adjust the equipment parameters in a timely manner.

2.3 Save from light

Light, especially ultraviolet rays, may trigger a photochemical reaction of 1-IB-2-MI, causing it to decompose or deteriorate. Therefore, when storing, try to avoid direct exposure to sunlight or other strong light sources. Opacity of opaque containers or packaging materials, such as dark glass bottles or metal cans, cans, can be selected to reduce the impact of light.

In addition, the storage area should be away from windows or light sources, so it is better to choose a dark warehouse or storage room. If it is necessary to store in a light environment, consider using a blackout blind or a reflector to further reduce the light intensity.

2.4 Sealed and stored

1-IB-2-MI has a certain volatile nature, especially in high temperature environments, which can easily escape the container. Therefore, it is necessary to ensure that the container is well sealed during storage to prevent compound leakage or from occurring with oxygen, moisture, etc. in the airreaction. It is recommended to use a glass bottle or metal can with a sealing cap and check the sealing performance regularly to ensure there is no gas leakage.

For large-scale storage, it is possible to consider using an inert gas (such as nitrogen) to fill the container to form a protective layer to further reduce the contact between the compound and the outside world. In addition, the storage area should be well ventilated to avoid safety hazards caused by the accumulation of volatiles.

2.5 Stay away from fire sources and oxidants

1-IB-2-MI has a flash point of 73°C. Although it is relatively safe at room temperature, it is still necessary to stay away from the fire source and high-temperature equipment to avoid fire or explosion accidents. The storage area should be equipped with fire extinguishing equipment, and fire safety inspections should be conducted regularly to ensure that emergency equipment is in a good condition.

In addition, 1-IB-2-MI should be avoided in co-stored with strong oxidants (such as hydrogen peroxide, nitric acid, etc.) because these substances may trigger severe chemical reactions, resulting in the occurrence of dangerous situations. It is recommended to store 1-IB-2-MI separately from other chemicals, and to set up special storage areas to reduce the risk of cross-contamination.

3. Safety regulations during transportation

3.1 Packaging Requirements

Packaging of 1-IB-2-MI is crucial during transportation. Suitable packaging not only protects the compounds from the outside environment, but also ensures safety during transportation. According to international standards (such as the United Nations Transport of Dangerous Goods), 1-IB-2-MI should use packaging materials that meet the requirements. The specific requirements are as follows:

  • Inner Packaging: It is recommended to use corrosion-resistant and permeable materials, such as polyethylene (PE) or polypropylene (PP) plastic bags to ensure that the compounds do not leak or contact the outside world.
  • External packaging: Rugged containers such as steel drums, iron drums or plastic drums should be selected to ensure that they are not damaged during transportation. For large-scale transportation, pallets or containers can be used to further improve safety.
  • Label logo: All packaging should be clearly marked with the name, ingredients, hazard level and emergency measures of 1-IB-2-MI. In addition, warning signs such as “flammable” and “corrosive” must be marked to remind relevant personnel to pay attention to safety.
3.2 Transportation method selection

The transportation mode of 1-IB-2-MI should be reasonably selected based on its physical and chemical properties. Common modes of transportation include road transport, rail transport and sea transport. Each method has its advantages and disadvantages. The specific choice should comprehensively consider factors such as transportation distance, time, and cost.

  • Road Transport: Suitable for short-distance transportation, high flexibility and can be delivered to the destination quickly. But needNote that the vehicle bumps during road transportation may cause damage or leakage of the packaging. Therefore, it is recommended to choose a transport vehicle with good shock absorption performance and ensure a secure packaging.
  • Rail Transport: Suitable for long-distance transportation, high safety and low transportation costs. The vehicles are relatively stable during railway transportation, reducing the risk of packaging damage. However, emergency response in emergencies may not be timely enough, and emergency plans need to be made in advance.
  • Sea Transportation: Suitable for cross-border transportation, with large capacity and low cost. However, due to the complex sea environment, it may be affected by weather, waves and other factors, increasing transportation risks. It is recommended to choose a container with moisture-proof and shock-proof functions, and regularly check the status of the goods to ensure transportation safety.
3.3 Temperature and humidity control

Displays in temperature and humidity during transportation may have an impact on the stability of 1-IB-2-MI. Therefore, transport vehicles or ships should be equipped with temperature and humidity control systems to ensure that the transportation environment meets storage requirements. Specific measures include:

  • Temperature Control: For long-distance transportation, it is recommended to use a refrigerated truck or refrigerated container to keep the temperature of the transportation environment between 10°C and 25°C. For short-distance transportation, air conditioning or fan can be installed in the car to ensure the appropriate temperature.
  • Humidity Control: During transportation, high humidity environments should be avoided, especially in rainy seasons or humid areas. Desiccant can be placed in the car or in the container to absorb excess moisture and keep the air dry. In addition, the packaging should be sealed and inspected before transportation to prevent moisture from entering.
3.4 Safety protection measures

In order to ensure safety during transportation, relevant personnel should take a series of protective measures to avoid accidents.

  • Personnel Training: All personnel involved in transportation should receive professional training to understand the physical and chemical properties of 1-IB-2-MI, and master the correct operating methods and emergency response measures. The training content should include knowledge in packaging, loading and unloading, transportation, storage, etc., to ensure that each link can be strictly implemented in accordance with regulations.
  • Emergency Plan: The transport unit should formulate a detailed emergency plan to clarify the handling steps in the event of leakage, fire and other emergencies. Emergency plans should include alarm procedures, evacuation routes, use of fire extinguishing equipment, etc., and conduct regular drills to ensure that relevant personnel can handle emergencies proficiently.
  • Safety Inspection: Vehicles, equipment, packaging, etc. should be comprehensively carried out before transportationCheck to make sure everything is OK. During transportation, the cargo status should be checked regularly and problems should be dealt with in a timely manner. After arriving at the destination, the goods should be accepted to ensure that there is no damage or leakage.

4. Relevant domestic and foreign regulations and standards

1-IB-2-MI storage and transportation must not only comply with internal regulations of the enterprise, but also comply with relevant national and international regulations and standards. The following are some commonly used regulations and standards at home and abroad for reference.

  • China: According to the “Regulations on the Safety Management of Hazardous Chemicals” and the “Characteristics and Labeling Specifications”, 1-IB-2-MI is a flammable liquid and must be stored in accordance with relevant regulations and transportation. In addition, standards such as “Vehicle Marking of Dangerous Goods in Road Transport” must be followed to ensure safety during transportation.
  • EU: The EU has formulated the “Regulations on the Transport of Dangerous Goods” (ADR), which clearly stipulates the classification, packaging, marking, transportation and other requirements of 1-IB-2-MI. In addition, the EU has also issued the “Regulations on Registration, Evaluation, Authorization and Restriction of Chemicals” (REACH), requiring companies to conduct detailed risk assessment and management of chemicals.
  • United States: The U.S.’s Dangerous Goods Transport Act (HMTA) and Occupational Safety and Health Act (OSHA) put forward strict requirements on the storage and transportation of 1-IB-2-MI . In addition, the American Chemical Commission (ACC) has released the Responsible Care® Program to encourage companies to adopt good practices in chemical management.
  • International: The United Nations Regulations on the Transport of Dangerous Goods (UN TDG) is a global standard that covers the requirements for the classification, packaging, marking, transportation of dangerous goods. 1-IB-2-MI, as a flammable liquid, must be classified according to UN No. 2810 and comply with the corresponding transportation regulations.

5. Conclusion

1-isobutyl-2-methylimidazole, as an important organic compound, needs special attention to factors such as temperature, humidity, light, and sealing during storage and transportation to ensure its stability and safety . By optimizing storage conditions and complying with transportation safety regulations, potential risks can be effectively reduced and the smooth progress of production and logistics can be ensured. At the same time, enterprises and practitioners should pay close attention to changes in relevant domestic and foreign laws and regulations and standards, update management systems in a timely manner, and ensure compliance operations.

I hope this article can provide valuable reference for readers engaged in 1-IB-2-MI related work, helping everyone better manage and use this compound.

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